Biography
Professor in the Department of Bioengineering and Therapeutic Sciences and Director of the Institute for Human Genetics at the University of California, San Francisco.
Positions
- He received his PhD in human genetics from Tel-Aviv University working on hereditary hearing loss.
- He then did his postdoc, specializing in functional genomics, in the Lawrence Berkeley National Laboratory and the DOE Joint Genome Institute.
- His current work is focused on identifying gene regulatory elements and linking nucleotide variation within them to various phenotypes including morphological differences between species, drug response and human disease.
- His lab was one of the co-developers of massively parallel reporter assays (MPRAs) that allow for high-throughput functional characterization of gene regulatory elements.
- In addition, he pioneered cis-regulation therapy (CRT), the use of gene regulatory elements as therapeutic targets for haploinsufficient disorders, and adipose modulation transplantation (AMT), a novel cancer cell therapy.
Areas of special interest
- Functional genomics & translational medicine
- Human genetics & disease
- Gene regulatory elements
- Nucleotide variation & phenotypes